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Vitamin B12 is necessary for patients with a low serum level of vitamin B12 because they take particular medications or because they suffer from pernicious anemia, gastrointestinal or autoimmune disorders, or alcoholism

They normally come from skin inflammation, which can have different causes

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Mechanistically, a 2026 PubMed review points to angiogenesis, collagen synthesis, fibroblast activity, and nitric oxide modulation as the likely pathways